Protein Kinase Antibodies

Protein kinase is an enzyme that is key in regulating cell function. Protein kinase helps with this cell function regulation by adding phosphate groups (phosphorylation) to proteins. It is part of a group of enzymes involved in signal transduction. There are multiple types of protein kinases represented in humans. There are serine/threonine-specific protein kinases which phosphorylate the OH group of serine or threonine. Tyrosine-specific protein kinases act against amino acid residues of tyrosine. Histidine specific protein kinases are found mostly in prokaryotes and work within the signal transduction mechanisms in prokaryotes in which the phosphate from ATP is added to histidine. Some kinases have mixed activities and can act against other types of proteins or even have affinity to work with more than one type of protein (thus have a dual or higher specificity). Protein kinase inhibitors effectively inhibit that step of the transcription process. Kinase can effectually be deregulated by many factors which, in the end, results in disastrous ends like cancer, disease, and even death. However, deregulated kinases can also be used to benefit individuals and treat different diseases as well.

FYN antibody binds to a tyrosine-protein kinase that acts to control the growth of cells. It plays a role in the regulation of intracellular ion levels, specifically the levels of calcium. Proper calcium levels are needed for proper brain development and brain function including axon growth and guidance, and neurite extension. The protein contains 1 protein kinase domain, one SH2 (src homology) domain, and one SH3 (src homology) domain. Src homology domains are found in oncoproteins and highly expressed in tumor formation. The ZAP70 antibody binds against the ZAP70 protein and plays a role in lymphocyte activation and T-cell development. Defects in ZAP70 cause STD or selective T-cell defect which is part of a group of severe combined immunodeficiency syndromes related to ZAP70. Affected individuals inherit the disorder. Children with SCID basically have no immune function and lack protection against invaders like bacteria, viruses, and fungi. Untreated, survival times are no longer than 1-2 years. Mutations in ZAP70 allow for mistakes in the synthesis of zeta-chain-associated protein kinase.