Antibodies by Host Species

• Goat Antibodies
• Hamster Antibodies
• Mouse Antibodies
• Rabbit Antibodies
• Rat Antibodies

There is typically more than one antibody available to bind against any given target. Antibodies for research or other applications are produced in vivo with the help and assistance of the immune systems of many different host species. Usually, the host species of an antibody should be the same as the target species of the study. This may not always be possible as antibodies produced in every species on Earth are not always available. Simply because the antibody is from a different host species, however, does not mean that it will not bind against the target antigen in the targeted species. Usually, the interaction has not been fully tested. Abcore Inc. sells many antibodies by many different host species. Listed on each are the tested species. Typically, a prediction of cross reactivity can be made based on sequence similarity. Generally, the species in which an antibody was raised will be more important when using a conjugated secondary antibody to detect an unconjugated primary antibody. Depending on application, a researcher may want to choose a primary antibody raised in a species as similar to the secondary antibody host species as possible. For other applications, a researcher may want to choose something as different as they can to show a greater degree of dissociation.

Anti-Met (c-Met) antibody binds against the target Met. Ant-Met antibody is raised in goat or rabbit. Met is localized in the cellular membrane and expressed in numerous types of tissues. C-Met is a receptor for growth and scatter hepatocyte factors. Met functions in cell proliferation, scattering, morphogenesis, and survival. It often acts as a tyrosine-protein kinase. When MET is activated after being rearranged with the TPR gene, an oncoprotein is produced. Defects in MET protein are thought to be involved in certain types of gastric cancer, kidney cancer, liver cancer, and autism. Hepatocellular carcinoma, as well as renal cell carcinoma papillary, are caused by defects in c-MET. Hepatocellular carcinoma is a primary liver cell tumor which occurs more frequently in human men than woman. HCC is often related to cirrhosis of the liver being caused by alcohol abuse, autoimmune liver diseases, hepatitis, and iron overload. Although treatment for hepatocellular carcinoma is available, it is rarely successful in removing and killing all of the cancer. Unfortunately, affected individuals are likely to die within 3-6 months. Renal cell carcinoma papillary is a rare genetic mutation in the c-met gene causing kidney cancer. Renal cell carcinoma is the most common type of kidney cancer that occurs in the papillary tubes that connect the kidneys to the bladder. The anti-Jagged1 antibody binds against a ligand for multiple Notch receptors. Jagged 1 is raised in rabbit and goat. Jagged1 is widely expressed in a variety of tissues in the cellular membrane. Jagged1 functions in the formation of blood cells and mammalian cardiovascular development. Defects in JAG1 cause Alagille syndrome type 1 and tetralogy of Fallot (TOF). Alagille syndrome is a genetic disorder of the liver, heart, kidney, and other systems. It is characterized by hepatic bile duct paucity, or a reduction in the amount of bile ducts and cholestasis (inability for bile to flow from the liver to the duodenum). Alagille syndrome is a form of arteriohepatic dysplasia which involves multisystem defects characterized by chronic cholestasis due to paucity of intrahepatic bile ducts, peripheral pulmonary artery stenosis, and dysplastic kidneys. Alagille syndrome is inherited by an autosomal dominant fashion. Tetralogy of Fallot is a congenital heart defect that is present at birth. Tetralogy of Fallot is characterized by low blood oxygenation with or without cyanosis or blue tinged skin.